Structure of PDB 8pw5 Chain o Binding Site BS02

Receptor Information

>8pw5 Chain o (length=227) Species: 10090 (Mus musculus)

MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKL
THTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTM
GHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPI
RMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEIC
GSNHSFMPIVLEMVPLKYFENWSASMI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8pw5 Chain o Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8pw5 SCAF1 drives the compositional diversity of mammalian respirasomes.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): D173 E198
• Binding residue (residue number reindexed from 1): D173 E198
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001666 response to hypoxia
• GO:0007595 lactation
• GO:0022900 electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0031966 mitochondrial membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:8pw5, PDBe:8pw5, PDBj:8pw5
• PDBsum: 8pw5
• PubMed: 38575788
• UniProt: P00405|COX2_MOUSE Cytochrome c oxidase subunit 2 (Gene Name=Mtco2)