Structure of PDB 8c01 Chain o Binding Site BS02

Receptor Information
>8c01 Chain o (length=314) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHVRALILDATPLITQSYTHYQNYAQSFYTTPTVFQEIKDAQARKNLEIW
QSLGTLKLVHPSENSIAKVSTFAKLTGDYSVLSANDLHILALTYELEIKL
NNGDWRLRKKPGGDWITPENLTEAIIKDSGEDTTGSLGVEAPENQVALAT
GDFAVQNVALQMNLNLMNFMSGLKIKRIRNYMLRCHACFKIFPLPKDGKP
KHFCASCGGQGTLLRCAVSVDSRTGNVTPHLKSNFQWNNRGNRYSVASPL
SKNSQKRYGKKGHVHSKPQENVILREDQKEYEKVIKQEEWTRRHNEKILN
VRIGKGRYVNSSKR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8c01 Chain o Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8c01 Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C304 C323 C326
Binding residue
(residue number reindexed from 1)		C185 C204 C207
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0004521 RNA endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0043248 proteasome assembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0030688 preribosome, small subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c01, PDBe:8c01, PDBj:8c01
PDBsum8c01
PubMed36996028
UniProtQ08444|NOB1_YEAST 20S-pre-rRNA D-site endonuclease NOB1 (Gene Name=NOB1)

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