Structure of PDB 7msz Chain o Binding Site BS02

Receptor Information

>7msz Chain o (length=87) Species: 83332 (Mycobacterium tuberculosis H37Rv)

ALTAEQKKEILRSYGLHETDTGSPEAQIALLTKRIADLTEHLKVHKHDHH
SRRGLLLLVGRRRRLIKYISQIDVERYRSLIERLGLR

Ligand information

>7msz Chain a (length=1519)

uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacac
augcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgg
gugaguaacacgugggugaucugcccugcacuucgggauaagccugggaa
acugggucuaauaccggauaggaccacgggaugcaugucuugugguggaa
agcgcuuuagcggugugggaugagcccgcggccuaucagcuuguuggugg
ggugacggccuaccaaggcgacgacggguagccggccugagagggugucc
ggccacacugggacugagauacggcccagacuccuacgggaggcagcagu
ggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcguggg
ggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccg
gguucucucggauugacgguagguggagaagaagcaccggccaacuacgu
gccagcagccgcgguaauacguagggugcgagcguuguccggaauuacug
ggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacg
gcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggg
gagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaa
caccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcga
aagcguggggagcgaacaggauuagauacccugguaguccacgccguaaa
cgguggguacuagguguggguuuccuuccuugggauccgugccguagcua
acgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaa
aggaauugacgggggcccgcacaagcggcggagcauguggauuaauucga
ugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuag
agauaggcguucccuuguggccugugugcagguggugcauggcugucguc
agcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuu
gucucauguugccagcacguaaugguggggacucgugagagacugccggg
gucaacucggaggaagguggggaugacgucaagucaucaugccccuuaug
uccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugcc
gcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucu
gcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaac
gcugcggugaauacguucccgggccuuguacacaccgcccgucacgucau
gaaagucgguaacacccgaagccaguggccuaacccucgggagggagcug
ucgaaggugggaucggcgauugggacgaagucguaacaagguagccguac
cggaaggugcggcuggauc

....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<
.<<<..<<<..<<....<<...<......>....>>...>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<....
..>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>....
...........>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<
<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>
>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>
>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<
<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<
<......>>>>>>>.......>>>>>....>..<<<<<(((...<<<<<.
....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........
<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<
<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<
<<<<<<....<<..<<<<<..<<<......>>>.....>>>>>...>>..
........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>..
..<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>......
....<<<<<<..<<<<<<<<<<...........>>>>>>>>>>...<<..
))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..
)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<.
.......>>..........<<<<<<<......<<<<<...<<<<.<.<..
..>.>.>>>>.............>>>>>.<<<.<<<..<<<<<<......
.<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<
.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<
.....>>>>>........>>>>.........>>>...>>>>>>>>>...>
>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<
....>>>....>....>>>.....>>>>>>>......<....<<<<<<<.
.......>>>>>>>....>.....>>>>>>....<<<<<<<.........
.>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<
<<..<<<<<<..<<<<....<.<<<<..<<<..<<<..>>>.>>>.>>>>
.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<
<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7msz Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K8 H18 D21 T22 G23 Q28 R35 H42 H48 D49 H51 S52 R54 R62 R65 Y69
• Binding residue (residue number reindexed from 1): K7 H17 D20 T21 G22 Q27 R34 H41 H47 D48 H50 S51 R53 R61 R64 Y68

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7msz, PDBe:7msz, PDBj:7msz
• PDBsum: 7msz
• PubMed: 35064151
• UniProt: P9WH55|RS15_MYCTU Small ribosomal subunit protein uS15 (Gene Name=rpsO)