Structure of PDB 7ega Chain o Binding Site BS02

Receptor Information

>7ega Chain o (length=1427) Species: 9823 (Sus scrofa)

SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEHGGCG
RYQPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYAR
PEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNE
QNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLK
GKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIV
TPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGY
KVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNA
DFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTA
VRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSL
IIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKS
LGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIA
DSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRI
LNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVE
GKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGR
EGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGED
GLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLS
NAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIF
HINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIH
LRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQS
LGEPATQMTLNTFHYKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSAR
DAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEM
PDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFND
DNAEKLVLRIRIMNSDENMDDDVFLRCIESNMLTDMTLQGIEQISKVYMH
LPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSN
DIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGH
LMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIML
GQLAPAGTGCFDLLLDAEKCKYGMEIP

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7ega Chain o Residue 2002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ega Structural insights into preinitiation complex assembly on core promoters.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): C111 C114 C154 C184
• Binding residue (residue number reindexed from 1): C101 C104 C144 C149
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.6: DNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription

External links

• PDB: RCSB:7ega, PDBe:7ega, PDBj:7ega
• PDBsum: 7ega
• PubMed: 33795473
• UniProt: A0A7M4DUC2