Structure of PDB 7o9m Chain n Binding Site BS02

Receptor Information

>7o9m Chain n (length=215) Species: 9606 (Homo sapiens)

KNRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEVNERHQILRPGL
RVLDCGAAPGAWSQVAVQKVNAAGTDPSSPVGFVLGVDLLHIFPLEGATF
LCPADVTDPRTSQRILEVLPGRRADVILSDMAPNATGFRDLDHDRLISLC
LTLLSVTPDILQPGGTFLCKTWAGSQSRRLQRRLTEEFQNVRIIKPEASR
KESSEVYFLATQYHG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7o9m Chain n Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o9m Structural basis for late maturation steps of the human mitoribosomal large subunit.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): R37 E226
• Binding residue (residue number reindexed from 1): R13 E202
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity

Biological Process

• GO:0000451 rRNA 2'-O-methylation
• GO:0001510 RNA methylation
• GO:0006364 rRNA processing
• GO:0031167 rRNA methylation
• GO:0032259 methylation
• GO:0042254 ribosome biogenesis
• GO:1902775 mitochondrial large ribosomal subunit assembly

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:7o9m, PDBe:7o9m, PDBj:7o9m
• PDBsum: 7o9m
• PubMed: 34135318
• UniProt: Q9UI43|MRM2_HUMAN rRNA methyltransferase 2, mitochondrial (Gene Name=MRM2)