Structure of PDB 6n8j Chain m Binding Site BS02

Receptor Information
>6n8j Chain m (length=378) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTGKKEKSRRIREGRVKGENFYRDSKRVKFLNMYTSGKEIRRAASFQDST
IPDARVQPDRRWFGNTRVISQDALARILDTESYADAFGPKAQRKRPLEDL
VKATNEDITKYEEKQVSKGQSKRIWNELYKVIDSSDVVIHVLDARDPLGT
RCKSVEEYMKKETPHKHLIYVLNKCDLVPTWVAAAWVKHLSKERPTLAFH
ASITNSFGKGSLIQLLRQFSQLHTQISVGFIGYPNTGKSSIINTLRKKKV
CQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSSKDSEEDILFRGVVRV
EHVTHPEQYIPGVLKRCQVKHLERTYEISGWKDATEFIEILARKQGRLLK
GGEPDESGVSKQILNDFNRGKIPWFVLP
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain6n8j Chain m Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6n8j Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K261 H287 A288 N325 K328 S329 V343 A344 E349 T350
Binding residue
(residue number reindexed from 1)		K174 H200 A201 N235 K238 S239 V253 A254 E259 T260
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0042254 ribosome biogenesis
GO:2000200 regulation of ribosomal subunit export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6n8j, PDBe:6n8j, PDBj:6n8j
PDBsum6n8j
PubMed30814529
UniProtP53742|NOG2_YEAST Nucleolar GTP-binding protein 2 (Gene Name=NOG2)

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