Structure of PDB 8s8h Chain k Binding Site BS02

Receptor Information

>8s8h Chain k (length=470) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIG
HVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPE
PDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSG
AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREE
SALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPR
DFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRP
GIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLC
RADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLE
PNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEK
HWRLIGWATIKKGTTLEPIA

Ligand information

Ligand ID

MET

InChI

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChIKey

FFEARJCKVFRZRR-BYPYZUCNSA-N

SMILES

Software	SMILES
CACTVS 3.341	CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCCC(C(=O)O)N
CACTVS 3.341	CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCC[C@@H](C(=O)O)N
ACDLabs 10.04	O=C(O)C(N)CCSC

Formula

C5 H11 N O2 S

Name

METHIONINE

PDB chain

8s8h Chain k Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8s8h Structural basis of AUC codon discrimination during translation initiation in yeast.
Resolution	4.0 Å
Binding residue (original residue number in PDB)	Y142 F381 E383 G397
Binding residue (residue number reindexed from 1)	Y85 F324 E326 G340
Annotation score	1

External links

PDB	RCSB:8s8h, PDBe:8s8h, PDBj:8s8h
PDBsum	8s8h
PubMed	39193907
UniProt	P32481\|IF2G_YEAST Eukaryotic translation initiation factor 2 subunit gamma (Gene Name=GCD11)

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