Structure of PDB 7pks Chain k Binding Site BS02

Receptor Information

>7pks Chain k (length=458) Species: 9606 (Homo sapiens)

PEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYI
TQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICP
ILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIK
AYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLI
TESTYSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWE
RMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKA
FDRAFADNPGPMVVFATPGHAGQSLQIFRKWAGNEKNMVIMPMQVEYMSF
SAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPA
NGETVTLPTSPSIPVGISLGLLKREMAQGLLPRLLHGTLIMKESNFRLVS
SEQALKEL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7pks Chain k Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pks Structural basis of Integrator-mediated transcription regulation.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): H68 H70 H157
• Binding residue (residue number reindexed from 1): H67 H69 H156
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.27.-

Gene Ontology

Molecular Function

• GO:0004521 RNA endonuclease activity
• GO:0005515 protein binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0016180 snRNA processing
• GO:0034243 regulation of transcription elongation by RNA polymerase II

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0032039 integrator complex
• GO:0072562 blood microparticle

External links

• PDB: RCSB:7pks, PDBe:7pks, PDBj:7pks
• PDBsum: 7pks
• PubMed: 34762484
• UniProt: Q5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)