Structure of PDB 6zce Chain k Binding Site BS02

Receptor Information
>6zce Chain k (length=579) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNSRIAIVSADKCKPKKCRQECKRSCPVVKTGKLCIEVTPTSKIAFISEI
LCIGCGICVKKCPFDAIQIINLPTNLEAHVTHRYSANSFKLHRLPTPRPG
QVLGLVGTNGIGKSTALKILAGKQKPNLGRFDDPPEWQEIIKYFRGSELQ
NYFTKMLEDDIKAIIKPQYVDNIPRAIKGPVQKVGELLKLRMEKSPEDVK
RYIKILQLENVLKRDIEKLSGGELQRFAIGMSCVQEADVYMFDEPSSYLD
VKQRLNAAQIIRSLLAPTKYVICVEHDLSVLDYLSDFVCIIYGVPSVYGV
VTLPASVREGINIFLDGHIPAENLRFRTFSYPSLKKTQGDFVLNVEEGEF
SDSEILVMMGENGTGKTTLIKLLAGALKPDEGQDIPKLNVSMKPQKIAPK
FPGTVRQLFFKKIRGQFLNPQFQTDVVKPLRIDDIIDQEVQHLSGGELQR
VAIVLALGIPADIYLIDEPSAYLDSEQRIICSKVIRRFILHNKKTAFIVE
HDFIMATYLADKVIVFEGIPSKNAHARAPESLLTGCNRFLKNLNVTFRRD
PNSFRPRINKLDSQMDKEQKSSGNYFFLD
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6zce Chain k Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zce A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Resolution5.3 Å
Binding residue
(original residue number in PDB)		T111 N112 G113 I114 G115 K116 S117
Binding residue
(residue number reindexed from 1)		T108 N109 G110 I111 G112 K113 S114
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006415 translational termination
GO:0032790 ribosome disassembly
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0045727 positive regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zce, PDBe:6zce, PDBj:6zce
PDBsum6zce
PubMed33289941
UniProtQ03195|RLI1_YEAST Translation initiation factor RLI1 (Gene Name=RLI1)

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