Structure of PDB 8fru Chain j Binding Site BS02

Receptor Information
>8fru Chain j (length=88) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASKGTASFGKRHTRIHGSCRRCGKHSFHLQKHECASCGYPSAKMRRYNWS
YKSLRRRTQGTGSMSHMRKVYRAYNSGTLKANARKYLA
Ligand information
>8fru Chain 1 (length=2551) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguac
gccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgg
gaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggc
ccgagggccccgcccgagagggugcaagccccguacggcgggcggcgagu
agcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcu
aaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacgguga
aaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccgg
cccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcg
agcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccg
ccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaa
aggcggugaucuaugcccggcgagggcgaggccgggcgaaagccuggugg
aggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugg
gggcgaaagacucaucgaaccgccugguagcugguugccuccgaaauguc
ucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccgg
cgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccc
cgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccu
ccugguaagcaggacgggcgaggcgggacgauccggacgccgggccaggg
ugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccg
aaucggccggcccggaaaauggagcgcgccggagccccggacccgcgccc
ggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaagg
cggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcag
uagccgcuacuccgcgccccggaggacugagggggagacggguuccgcgg
cgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagacc
gggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggc
aggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggac
cgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgcc
uugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgcc
ccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcagga
cuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagu
cggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgg
gucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacag
cgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagug
ccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcggg
aguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuucc
gacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuc
cgcgagccuccagccucgggaacgggcgagggccggccagcggggcaaga
agacccuuuugagcuugacuccagcccgggccuguggggcgggggccgcc
gccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucg
gcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggc
ucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccg
acccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauc
cuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagg
gauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugau
ccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgu
cggauuguucacccguucaagggaucgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuggccccggggccagagcacggcgggcc
aguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggc
cgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucua
agcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgug
ccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuc
cuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcg
c
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>
>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<
......>>>>>((......<<<.....))>>>...>>>>>>>>.......
.<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]].
.................................<<....>>.........
.......<<<....>>>............................<<<<<
<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<.
.<<<...<<<....>>>..>>>...<<....>>............<<<<<
<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..
<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>..
...>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>..
.<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<
<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<
<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<
<(((...<<<<<<<........<<<.<<<<<<<<<...............
..>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>
>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<
<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<...
..<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<
...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>
......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>
))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<
<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.
....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.
........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.
>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<
<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<
<<<.......>>>>>>........<...........<<<<<<.....>>>
>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>
>>>....>>....<<<<<........>>>>>...((((((..{{{.....
....{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<........
.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...
<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<
...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>..
.<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......
(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<.
..............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}
.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........
>>>>>>...>>>..>>>..>>>>>....<<<<<<................
............>>>>>>.....<<<<<.......>>>>..<<<<<<<<<
<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>..
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fru The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		A5 S13 K14 T16 A17 S18 F19 G20 K21 R22 H23 T24 R25 I26 H27 H39 Q41 K42 A46 K54 R56 Y58 N59 W60 Y62 K63 R66 R67
Binding residue
(residue number reindexed from 1)		A1 S2 K3 T5 A6 S7 F8 G9 K10 R11 H12 T13 R14 I15 H16 H28 Q30 K31 A35 K43 R45 Y47 N48 W49 Y51 K52 R55 R56
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fru, PDBe:8fru, PDBj:8fru
PDBsum8fru
PubMed38242118
UniProtV6TG99

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