Structure of PDB 8cas Chain j Binding Site BS02

Receptor Information
>8cas Chain j (length=249) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELS
RRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKY
QKSKTVHSILRYCAEKFQIPLEELYKTIAWPLSRKFGHAYEAFKLSIIDE
TVWEGIEPPSKDVLDELKNYISVKIRADVEVSCFSYEGIDAIKDALKSAE
DVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNIT
Ligand information
>8cas Chain 2 (length=1763) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuacaugguauaacugugguaau
ucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauu
uauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaac
uuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugc
ccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgggu
aacggggaauaaggguucgauuccggagagggagccugagaaacggcuac
cacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagg
gagguagugacaauaaauaacgauacagggcccauucgggucuuguaauu
ggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagu
cuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaagu
uguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguc
ggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaacc
aggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcuc
gaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguu
gguuucuaggaccaucguaaugauuaauagggacggucgggggcaucagu
auucaauugucagaggugaaauucuuggauuuauugaagacuaacuacug
cgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggg
gaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccga
cuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaga
aaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuu
aaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauu
ugacucaacacggggaaacucaccagguccagacacaauaaggauugaca
gauugagagcucuuucuugauuuugugggugguggugcauggccguucuu
aguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuua
accuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagg
gacuaucgguuucaagccgauggaaguuugaggcaauaacaggucuguga
ugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcg
agucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgug
cuggggauagagcauuguaauuauugcucuucaacgaggaauuccuagua
agcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacac
cgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugc
uuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuug
gucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccug
cggaaggaucauu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..........<.....<<.<<<....
.>>>.>>......>.........<<<<<..<<....>>..>>>>><.<.<
<<<<<......(((((((.<<<....>>>..............>>>>>>.
>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.
<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.
..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>
>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>
..>>>..>....>.>.....<<<<<<<.<.<<<....>>>.>.>>>>.>>
>......<<..<...........>..>>.........<<<<<((....<.
<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>....
.....<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<.......
.......>>>>.>>>>>>....<<<<<<....................>>
>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>.
...>>......>>.>>..>>>.........<<<..<<<<<<<<.....))
))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<.
.<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<
<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<
<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..
]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>
..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......
<<........>>..........<<<<<.<....<<<<<........<<.<
<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<...
.<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<
.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>
....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>
>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......
<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...
...<....<<<<<<..........>>>>>>....>.....>>>>>>....
<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>...
.<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<
<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>
>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>
>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cas Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R54 R55 R88
Binding residue
(residue number reindexed from 1)		R52 R53 R86
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0043022 ribosome binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0010494 cytoplasmic stress granule
GO:0033290 eukaryotic 48S preinitiation complex
GO:0043614 multi-eIF complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cas, PDBe:8cas, PDBj:8cas
PDBsum8cas
PubMed37169754
UniProtP20459|IF2A_YEAST Eukaryotic translation initiation factor 2 subunit alpha (Gene Name=SUI2)

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