Structure of PDB 7nwh Chain j Binding Site BS02

Receptor Information

>7nwh Chain j (length=86) Species: 9986 (Oryctolagus cuniculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>7nwh Chain 8 (length=151)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaac
gcacuugcggccccggguuccucccggggcuacgccugucugagcgucgc
u

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>........>>>..)...>>>....
<<<..>>><<<<<<<<.......>>>>>>>>...................
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nwh Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): R20 R21 Y39 K42 T59 G62 R63 M64 R72 F74 R79 T82 P84 P86 K87
• Binding residue (residue number reindexed from 1): R19 R20 Y38 K41 T58 G61 R62 M63 R71 F73 R78 T81 P83 P85 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7nwh, PDBe:7nwh, PDBj:7nwh
• PDBsum: 7nwh
• PubMed: 34157102
• UniProt: U3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)