Structure of PDB 6az3 Chain j Binding Site BS02

Receptor Information
>6az3 Chain j (length=80) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTP
Ligand information
>6az3 Chain 2 (length=1078) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguauaucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgagcuucacuuaucgaau
gaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuu
ccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagac
aucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaa
cgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaac
acaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacu
gcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaa
ucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacu
gacagggaacgugagcuggguuuagaccgucgugagacagguugguuuua
cccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgug
cgagcgguggguguacgguacgcucacc
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.
....<<<<...........<.<<<..........>>>.>...........
.....................<<<<....>>>>..>>>>...>>>>>...
....>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<
<<....>>>.>>........<<<<<<..............<<<<......
.>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<
<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<
<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>......................<<.......>>.<.<>
.>.<.<<.....<<<...>>>..>>.>.
Receptor-Ligand Complex Structure
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PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		T2 K3 T5 T6 M8 G9 Q10
Binding residue
(residue number reindexed from 1)		T1 K2 T4 T5 M7 G8 Q9
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtP62885|RL37_LEIDO Large ribosomal subunit protein eL37 (Gene Name=RPL37)

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