Structure of PDB 6la2 Chain i Binding Site BS02

Receptor Information

>6la2 Chain i (length=100) Species: 9606 (Homo sapiens)

KKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQ
SSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Ligand information

>6la2 Chain d (length=343)

cgctgttttttttcatgtgccggtctcacacgtgcctggagactagtaag
cgcttctagtggcggttaaaacgcggtagacagcgcgtacgtgcgtttaa
gcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggatg
cgttttttttttcatactcgagcatgcttttttttttcatgtgccggtct
cacacgtgcctggagactagtaagcgcttctagtggcggttaaaacgcgg
tagacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaa
ttgagcggcctcggcaccgggatgcgttttttttcagcggtac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6la2 Engineering nucleosomes for generating diverse chromatin assemblies.
• Resolution: 3.89 Å
• Binding residue (original residue number in PDB): H39 R40 Y41 P43 G44 V46 R49 R63 K64 L65 P66 R69 R83
• Binding residue (residue number reindexed from 1): H4 R5 Y6 P8 G9 V11 R14 R28 K29 L30 P31 R34 R48

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0045296 cadherin binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0006334 nucleosome assembly
• GO:0010467 gene expression
• GO:0032200 telomere organization
• GO:0040029 epigenetic regulation of gene expression

Cellular Component

• GO:0000786 nucleosome
• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6la2, PDBe:6la2, PDBj:6la2
• PDBsum: 6la2
• PubMed: 33590100
• UniProt: P68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)