Structure of PDB 7pfe Chain h Binding Site BS02

Receptor Information
>7pfe Chain h (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASR
LAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSA
Ligand information
>7pfe Chain I (length=177) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcactggccgccatactggagaatcccggtgccgaggccgctcaattggt
cgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcg
ttttaaccgccaaggggattactccctagtctccaggcacgtgtcagata
tatacatcctgtcatgtaagtattaag
Receptor-Ligand Complex Structure
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PDB7pfe Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		R31 R33 K34 S36 V39 Y40 K43
Binding residue
(residue number reindexed from 1)		R2 R4 K5 S7 V10 Y11 K14
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfe, PDBe:7pfe, PDBj:7pfe
PDBsum7pfe
PubMed35581345
UniProtO60814|H2B1K_HUMAN Histone H2B type 1-K (Gene Name=H2BC12)

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