Structure of PDB 6az3 Chain h Binding Site BS02

Receptor Information
>6az3 Chain h (length=125) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CPRVQYRRRMHYATRGNRMKMVRTPGNKLVMQKRAKRSQGIHTPWVLGHK
RLGGTKALRHIDARLASRHEKSVSRAYGGVLSHDQVRDRVVRAFLVEEQR
IVKQALKEHSKMKLSHKRTANKKKS
Ligand information
>6az3 Chain 2 (length=1078) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguauaucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgagcuucacuuaucgaau
gaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuu
ccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagac
aucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaa
cgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaac
acaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacu
gcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaa
ucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacu
gacagggaacgugagcuggguuuagaccgucgugagacagguugguuuua
cccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgug
cgagcgguggguguacgguacgcucacc
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.
....<<<<...........<.<<<..........>>>.>...........
.....................<<<<....>>>>..>>>>...>>>>>...
....>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<
<<....>>>.>>........<<<<<<..............<<<<......
.>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<
<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<
<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>......................<<.......>>.<.<>
.>.<.<<.....<<<...>>>..>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C3 R5 V6 Y8 R11 Y14 R91 R94 A95 E99 R102 K105 L116
Binding residue
(residue number reindexed from 1)		C1 R3 V4 Y6 R9 Y12 R89 R92 A93 E97 R100 K103 L114
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtA0A3Q8IHK2

[Back to BioLiP]