Structure of PDB 5mei Chain h Binding Site BS02

Receptor Information
>5mei Chain h (length=318) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDD
QKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQ
RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWV
SQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINT
LTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYW
LAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTL
FAGYTDNVIRVWQVMTAN
Ligand information
Ligand IDOHX
InChIInChI=1S/6H2N.Os/h6*1H2;/q6*-1;+6
InChIKeyOWCQTVJQFLTQTE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.370
OpenEye OEToolkits 1.7.0		N[Os](N)(N)(N)(N)N
FormulaH12 N6 Os
Nameosmium (III) hexammine;
osmium(6+) hexaazanide
ChEMBL
DrugBank
ZINC
PDB chain5mei Chain h Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mei Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		F278 G280 E286
Binding residue
(residue number reindexed from 1)		F277 G279 E285
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001965 G-protein alpha-subunit binding
GO:0005080 protein kinase C binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0043022 ribosome binding
GO:0045182 translation regulator activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006521 regulation of cellular amino acid metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0061157 mRNA destabilization
GO:0070651 nonfunctional rRNA decay
GO:0072344 rescue of stalled ribosome
GO:1902660 negative regulation of glucose mediated signaling pathway
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990145 maintenance of translational fidelity
GO:2001125 negative regulation of translational frameshifting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mei, PDBe:5mei, PDBj:5mei
PDBsum5mei
PubMed28457705
UniProtP38011|GBLP_YEAST Small ribosomal subunit protein RACK1 (Gene Name=ASC1)

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