Structure of PDB 8rbz Chain g Binding Site BS02

Receptor Information
>8rbz Chain g (length=886) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLAD
VFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSK
DFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQ
LVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKR
LAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSG
TIAIKHYFRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLA
LEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVV
ETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRS
ATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIAR
QASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEE
NYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAF
SQLICTCNSLKTSPPPAIALQRCGRISNQMKQSMEEFRSLASRYGDLYQA
SFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHAD
SEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSF
QRYFFQKLQSTSIKLALSPPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQ
SVCLNVSSTLQSNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESS
VKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQ
Ligand information
>8rbz Chain r (length=27) Species: 7111 (Trichoplusia ni) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DVSVWEENWEDDIVQDDFNQQLRLEME
Receptor-Ligand Complex Structure
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PDB8rbz Structural basis of Integrator-dependent RNA polymerase II termination
Resolution3.7 Å
Binding residue
(original residue number in PDB)		H451 C452 A454 A455 V491 G523 W524 Y527 R528 R531 R535 A554 S555 F558 Q792 R793 F796
Binding residue
(residue number reindexed from 1)		H420 C421 A423 A424 V460 G492 W493 Y496 R497 R500 R504 A523 S524 F527 Q751 R752 F755
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006974 DNA damage response
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbz, PDBe:8rbz, PDBj:8rbz
PDBsum8rbz
PubMed38570683
UniProtQ9NVH2|INT7_HUMAN Integrator complex subunit 7 (Gene Name=INTS7)

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