Structure of PDB 8rbx Chain g Binding Site BS02

Receptor Information
>8rbx Chain g (length=886) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLAD
VFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSK
DFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQ
LVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKR
LAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSG
TIAIKHYFRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLA
LEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVV
ETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRS
ATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIAR
QASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEE
NYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAF
SQLICTCNSLKTSPPPAIALQRCGRISNQMKQSMEEFRSLASRYGDLYQA
SFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHAD
SEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSF
QRYFFQKLQSTSIKLALSPPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQ
SVCLNVSSTLQSNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESS
VKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQ
Ligand information
>8rbx Chain r (length=28) Species: 7111 (Trichoplusia ni) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DVSVWEENWEDDIVQDDFNQQLRLEMFR
Receptor-Ligand Complex Structure
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PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
Resolution4.1 Å
Binding residue
(original residue number in PDB)		N414 C452 A454 N522 G523 W524 Y527 R531 Q532 R535 L549 A554 S555 F558 W561 N612 Q792 R793 F796 Q797 K798
Binding residue
(residue number reindexed from 1)		N383 C421 A423 N491 G492 W493 Y496 R500 Q501 R504 L518 A523 S524 F527 W530 N581 Q751 R752 F755 Q756 K757
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006974 DNA damage response
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtQ9NVH2|INT7_HUMAN Integrator complex subunit 7 (Gene Name=INTS7)

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