Structure of PDB 8h0v Chain g Binding Site BS02

Receptor Information
>8h0v Chain g (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLPK
Ligand information
>8h0v Chain N (length=201) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctttaaagcaaacggtccacttgtgtttggtgtgtttgggaatccggtgc
cgaggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacg
tacgcgctgtcccccgcgttttaaccgccaaggggattactccctagtct
ccaggcacgtgtcagatatatacatccaggccttgtgtcgcgaaattcat
a
Receptor-Ligand Complex Structure
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PDB8h0v Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 G44 K75 T76 R77
Binding residue
(residue number reindexed from 1)		R16 R29 V30 G31 K62 T63 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0v, PDBe:8h0v, PDBj:8h0v
PDBsum8h0v
PubMed36435862
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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