Structure of PDB 8tym Chain f Binding Site BS02

Receptor Information

>8tym Chain f (length=693) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGASSVLENFVGRDFLP
RGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRV
TGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRD
MLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLD
LMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKF
FLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIE
KEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSG
GARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMA
FETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMER
IVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGIRKGWLTINNIGI
MKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSK
HIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPEMDPQL
ERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANL
YSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGNINTT

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8tym Chain f Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8tym Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission.
Resolution	3.58 Å
Binding residue (original residue number in PDB)	S45 T65
Binding residue (residue number reindexed from 1)	S37 T57
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.5.5: dynamin GTPase.

External links

PDB	RCSB:8tym, PDBe:8tym, PDBj:8tym
PDBsum	8tym
PubMed	38663399
UniProt	Q05193\|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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