Structure of PDB 8rbx Chain f Binding Site BS02

Receptor Information
>8rbx Chain f (length=544) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRY
MLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLN
LNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNS
PLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMC
EVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSQPWHSCH
KLIYVRPNVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVI
DKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLK
ASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKPTLKWRQSFESYLKTMPP
YYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVI
GSVGKKVVQETGIKVRSRGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLT
RMRSNLLKSQVHSVPIAQMGNYQEYLKQVPSPLRELGMMIDEAD
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8rbx Chain f Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D629 E630
Binding residue
(residue number reindexed from 1)		D541 E542
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0015629 actin cytoskeleton
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtQ9UL03|INT6_HUMAN Integrator complex subunit 6 (Gene Name=INTS6)

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