Structure of PDB 7a01 Chain c3 Binding Site BS02

Receptor Information
>7a01 Chain c3 (length=206) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG
Ligand information
>7a01 Chain K3 (length=1801) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucagaucaaaaccaacccggucagccccu
ggcgggcgccggcggcuuuggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcgggcgggcgcgcccguccccgcc
ccuugccucucggcgcccgggcccgaagcguuuacuuugaaaaaauuaga
guguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaugg
aauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauu
aagagggacggccgggggcauucguauugcgccgcuagaggugaaauucu
uggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuu
cauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucg
uaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauuccc
augacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggg
gaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccac
caggaguggagccugcggcuuaauuugacucaacacgggaaaccucaccc
ggcccggacacggacaggauugacagauugauagcucuuucucgauuccg
ugggugguggugcauggccguucuuaguugguggagcgauuugucugguu
aauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccc
cgagcggucggcgucccccaacuucuuagagggacaaguggcguucagcc
acccgagauugagcaauaacaggucugugaugcccuuagauguccggggc
ugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggc
aggcgcggguaacccguugaaccccauucgugauggggaucggggauugc
aauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuu
gcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccg
auuggaugguuuagugaggcccucggaucggccccgccggggucggccca
cggcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu
a
...<<<<<.{.[[[[>>>>><<<.<<<<<<...<.<<.........<<<.
<<<...<....<......<..........>.....>.>.......<<...
.....<<<......<<......<....................<<.....
<<.............>>......>>.........<<<<...<<<<<....
..>>>>>...>>>>....<<<<<......(((((......<....<<...
....>>......>................>>>>>...........<<<<.
.<<<......>>>.>>>>...>......>>....>>>.<<<....<<<..
...<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>
.>...>>>>>>.........<<<....<<<.....>>>..>>>......>
>.>.....<<.<<<<<<.<........>.>>.>>>>..>>....<.<<..
...............>>......>..<<<<<((......<<<<.....<<
..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.
....<.<<....<<.<<.....<<.<<<<<<<<<<..>>>>>..>>>>>>
>........<<<<.<<<<>>>>>>>>.....<<<<<<.<.......<<..
.<.......>..<<<.......>>>....>>......>.>>>..>>>...
.....<.....<<<.<.........)))))...>.>>>.....>....>>
....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>
>...>>....>>.>....<<<<<<<...<...<<<<.........>>>>.
..>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<.....
.>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>.>.>.<<<
......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<
..<<<<...<<<.<<<<<<.......<........>...........<<<
<<.<....<<<<<........<<..<<........>>.>>.......>>>
>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<..
....>>>...>>.>>>....<<<.......<<.....<<.....<<.<<.
.<......>>>..>>.....>>.....>>........<<<<<.....>>>
>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>..
.>>.>>>>.>>>.....<<.<<<................<<<.<<<<...
.>>>>.>>>..............>>>.>>......<.....<<<<<....
......>>>>>.....>......>>>>......<<<<<<<.......>>>
>>>>.......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<.
...<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..<.......
..>..>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>........
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a01 The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
G2 R5 D6 N7 H9 K10 R11 R12 T14 R18 K19 P20 Y21 H22 K23 K24 R25 K26 Y27 L29 R31 R41 I43 T45 R47 V48 R49 G50 G51 K54 Y55 R56 R59 N64 S66 C71 C72 T73 R74 K75 A85 S86 V97 K98 W112 H116 Y117 K140 R141 K143 K144 K147 Y149 R178 G180 Q181 G183 R184 D186 G187 Y188
Binding residue
(residue number reindexed from 1)
G1 R4 D5 N6 H8 K9 R10 R11 T13 R17 K18 P19 Y20 H21 K22 K23 R24 K25 Y26 L28 R30 R40 I42 T44 R46 V47 R48 G49 G50 K53 Y54 R55 R58 N63 S65 C70 C71 T72 R73 K74 A84 S85 V96 K97 W111 H115 Y116 K139 R140 K142 K143 K146 Y148 R177 G179 Q180 G182 R183 D185 G186 Y187
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7a01, PDBe:7a01, PDBj:7a01
PDBsum7a01
PubMed33296660
UniProtG1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)

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