Structure of PDB 8iuj Chain c2 Binding Site BS02

Receptor Information

>8iuj Chain c2 (length=196) Species: 3039 (Euglena gracilis)

MRYGNREIESIILFFDQTIILYTSIINALIVGIIIIIRKWYNRKGICNQY
IYHIKIEVIWTILPIIFLIVIVLHSVTVIYNLEINKGTNNKYINVIGNQW
YWIYNNIESRISSLGRIILVDQPLFIKANNNTHLIISSLDVIHSFALPTL
GIKVDAIPGRINNISINGLTQGLYVGYCSELCGSGHAFMPINLIVY

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 8iuj Chain c2 Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8iuj Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism.
• Resolution: 3.06 Å
• Binding residue (original residue number in PDB): C178 E180 C182 H186
• Binding residue (residue number reindexed from 1): C178 E180 C182 H186
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8iuj, PDBe:8iuj, PDBj:8iuj
• PDBsum: 8iuj
• PubMed: 38388527
• UniProt: Q9XN19