Structure of PDB 8h0w Chain c Binding Site BS02

Receptor Information
>8h0w Chain c (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLPK
Ligand information
>8h0w Chain N (length=196) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttaaagcaataggtccacttgtgtttggtgtgtttgggaatccggtgccg
aggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacgta
cgcgctgtcccccgcgttttaaccgccaaggggattactccctagtctcc
aggcacgtgtcagatatatacatccaggccttgtgtcgcgaaattc
Receptor-Ligand Complex Structure
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PDB8h0w Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		K15 T16 R17 R32 R42
Binding residue
(residue number reindexed from 1)		K2 T3 R4 R19 R29
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h0w, PDBe:8h0w, PDBj:8h0w
PDBsum8h0w
PubMed36435862
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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