Structure of PDB 7syi Chain c Binding Site BS02

Receptor Information

>7syi Chain c (length=83) Species: 9986 (Oryctolagus cuniculus)

PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQ
TVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH

Ligand information

>7syi Chain z (length=162)

cccccccucccgggagagccauaguggucugcggaaccggugaguacacc
ggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguuggg
ucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccg
ggaggucucgua

.....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>
>><<...>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<......
..>>....>>>....>>>>.>><<<......>>><<...((((.>>>>>>
>>>>>.))))..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7syi Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Resolution: 4.5 Å
• Binding residue (original residue number in PDB): D34 K36 Y41 I43 R80
• Binding residue (residue number reindexed from 1): D33 K35 Y40 I42 R79

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0046872 metal ion binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7syi, PDBe:7syi, PDBj:7syi
• PDBsum: 7syi
• PubMed: 35822879
• UniProt: G1TZ76|RS27_RABIT Small ribosomal subunit protein eS27 (Gene Name=RPS27)