Structure of PDB 5umd Chain c Binding Site BS02

Receptor Information

>5umd Chain c (length=89) Species: 36329 (Plasmodium falciparum 3D7)

GKAGKGTGSFGKRNGKTHFLCLRCGKRSYHLQKKKCASCGYPSAKKRRFN
WSVKAKRRNTTGTGRCRYIKTLRRKLKNKFTEGSTPKPK

Ligand information

>5umd Chain C (length=151)

agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgc
agcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaug
cugaauguaaacuacaccaauucccugggaauagugguacuccuacagaa
a

............................................<<<<<<
.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>
>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K17 F20 L23 R24 C25 G26 Y30 L32 Y42 A45 T62 T64 G65 R66 C67 R68 Y69 I70 K71 L73 R75 K76 N79 F81 G84 S85 P87 K88 P89 K90
• Binding residue (residue number reindexed from 1): K16 F19 L22 R23 C24 G25 Y29 L31 Y41 A44 T61 T63 G64 R65 C66 R67 Y68 I69 K70 L72 R74 K75 N78 F80 G83 S84 P86 K87 P88 K89

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5umd, PDBe:5umd, PDBj:5umd
• PDBsum: 5umd
• PubMed: 28288098
• UniProt: C0H4L5