Structure of PDB 7zx7 Chain b Binding Site BS02

Receptor Information
>7zx7 Chain b (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPPAADSDREDAA
VARDLDCSLEAAAELRAVCGLDEVIPENTDLVTLGVRKRFLEHREETITI
DRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHKHK
EHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQAPEHISKDL
YKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDF
TFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKK
HWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKL
GEFLAYPYVDPGTFN
Ligand information
>7zx7 Chain T (length=66) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtaagtatgaaacgttgtgcctctgccccgacacagcctcatacgcctca
ctctttacacacacgg
Receptor-Ligand Complex Structure
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PDB7zx7 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R148 R151 E197 W348 W350 T351
Binding residue
(residue number reindexed from 1)		R102 R105 E151 W302 W304 T305
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003681 bent DNA binding
GO:0005515 protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0006383 transcription by RNA polymerase III
GO:0009301 snRNA transcription
GO:0042795 snRNA transcription by RNA polymerase II
GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016604 nuclear body
GO:0019185 snRNA-activating protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zx7, PDBe:7zx7, PDBj:7zx7
PDBsum7zx7
PubMed36424526
UniProtQ92966|SNPC3_HUMAN snRNA-activating protein complex subunit 3 (Gene Name=SNAPC3)

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