Structure of PDB 7pny Chain b Binding Site BS02

Receptor Information
>7pny Chain b (length=307) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDR
DPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDL
GCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALA
SILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTR
KDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALS
FHSLEDRIVKRFLLGISMTRAPLMWELIHKKVLSPQDQDVQDNPRGRSAK
LRAAIKL
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain7pny Chain b Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7pny Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		T96 F97 G98 S99 G100 D119 R120 Q145 F146 D169 G171 C172 S173 Q176 M196 E298
Binding residue
(residue number reindexed from 1)		T26 F27 G28 S29 G30 D49 R50 Q75 F76 D99 G101 C102 S103 Q106 M126 E228
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pny, PDBe:7pny, PDBj:7pny
PDBsum7pny
PubMed35676484
UniProtA6NJ78|MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (Gene Name=METTL15)

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