Structure of PDB 6c0f Chain b Binding Site BS02

Receptor Information

>6c0f Chain b (length=242) Species: 1247190 (Saccharomyces cerevisiae BY4741)

QRTLLISSRGVNYRHRHLIQDLSGLLPHSRKEPKLDTKKDLQQLNEIAEL
YNCNNVLFFEARKHQDLYLWLSKPPNGPTIKFYIQNLHTMDEAAAAAAAA
AGSRPVLSFDQRFESSPHYQLIKELLVHNFGVPPAAAAAAAAADHVMSFS
IVDDKIWVRTYESLVEIGPRFVMTVILILEGSFGGPKIYENKQYVSPNVV
RAQIKQQAAEEAKSRAEAAVERKIKRRENVLAADPLSNDALF

Ligand information

>6c0f Chain x (length=28) Species: 1247190 (Saccharomyces cerevisiae BY4741)

AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6c0f Modular assembly of the nucleolar pre-60S ribosomal subunit.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): R32 N82 N84 P105 E228 P234
• Binding residue (residue number reindexed from 1): R2 N52 N54 P75 E180 P186

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding
• GO:0042134 rRNA primary transcript binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:6c0f, PDBe:6c0f, PDBj:6c0f
• PDBsum: 6c0f
• PubMed: 29512650
• UniProt: Q08235|BRX1_YEAST Ribosome biogenesis protein BRX1 (Gene Name=BRX1)