Structure of PDB 7aor Chain aa Binding Site BS02

Receptor Information

>7aor Chain aa (length=1558) Species: 353153 (Trypanosoma cruzi strain CL Brener)

SFKYATKLQHDEMRQPFYIHEKRHGIFSNEKNIRKSRRGLPFITPLYTRH
MNLWETDTDASKNRFFRGYVFGQRELHQLLGRPHGFEANNTDGSNDISAY
EMTTDQRYKGIPRPAITNLHYEPEWNYTLYRAGTHGSQLSNPRSPLTAEV
LGDELMKIRDIKSFDHCKAWFDRLQYLIKLHYDAVGDIGEFKSRHTQHVH
EFFVAFHDALSSFDFGDSYLFEQFHAARPSELTDLFGIFLEMEANYVHED
YCPRCSLPYSTTRYCGEGDANTPFRKHRGRWAPHQRWGREWYAVVARRAE
ALWYRATEDPYFGTPQHTQRQAEALLRVYVQTKQRGKAIDFMNALRGSKE
FLLGSICITPEMQESYDRLLDTTPHPHLLTNGFTLESNAAKYTGEVQKVP
FSPLQFRIDMEMNKYRRQQKEEGAVRVPPAMWRIDTSAIVPYKVDPKTKR
VINWREVKEGIEKSFLSTGLPKEAYTGSEWREMLHLKSIIAGRAAKAAEL
ERRLHTDKVKLLEVSSKSKIASETNTSTGSSNSSSIIFPDKDGYHVFDTS
VASLRPFGVSQSGAVFQSVTHTYPSPHAVLYNDPVHGKQFILDTTNESCH
LFGGFEHGDRLLIRARKIDKNDNNPNSVLAVKGNEFEVIVVGVNKEGSDS
EWQLCAMHVDPALQREYGLVFLGTDCVDIHERWASVRYAAAAPHVKGRVT
LLEERRTAREESLGQIVGVRDGVLFVQWRLLRGGGSEMDRSVAEPIGTVE
QVRNAYQITEQGVEELMHPPSWRTPFRNDFAEERLEELRQAPFKRENWVS
LIQGRYTPKLKRFGYTQHTTMDDFETKEYKDRLLSKQFFHNPQAFEVIPD
RRDRAVTFGGKWEYQRTHGLPTVDRNELENGWSEVEAVTDAEMHVIEQAL
RDISGRRPGNFIKSPTKKNTLQLNESWWEPLEFGWEQHNKEQKALVDPTE
QRLIDSASLPFGGKIPPFGTTIGIGERIREIAEDYAKGFGLGPHGHSPSH
DTCQYNTLNAEEDRVRELGYKDALVRLFDEKMADKDVHQWAVEQCADGEA
DVRQLLLSLHEWRERGRPPSLMLLQVLSKYLEQEIAAFNEGVPSSVPKLS
LQTVDGTLSPSGNSGERSGTIWADVEPTAYALQYASQANHSSLDEPFILQ
LLKSAQLGGRNAQFTDPFYNAYLENSVVSEFQLGLAALAGKGVSPSLLAQ
KISQLHRGSVRLSGNVIPFVKSRELAHLLERMGLSSENIAVVTRGLANCP
EQESVGDDFAVPVSVILSWGGKMMVHVIEELALRDDGLVMDIQYIVRENR
RNPVLRHEFFAALLPVFAGKHEKVAQLYDEYCEGKYVPNITLAIEAFIAF
LCNVTKHADVYPGSSYFDVDTTNGPNAGQYISLKLLDPLDGPFIFDNIKA
EHIETVERFKQHGIQVGPVRAPATGFIAANSKSLSYFTRRPEEVVYVSTD
ADQGLRRSLERSAHYKTIAASPAMQFLLHTQNGAGLVATFNRFFYRTMPM
LSFYQRILKHYSDNVQPLRQKAQNSVRGLARVLENERSAAMEEFRRNSER
YWRNVLEG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7aor Chain aa Residue 1901

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7aor Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): C341 C354 H373
• Binding residue (residue number reindexed from 1): C252 C265 H284
• Annotation score: 4

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7aor, PDBe:7aor, PDBj:7aor
• PDBsum: 7aor
• PubMed: 33168716
• UniProt: Q4DVD2