Structure of PDB 8agv Chain a Binding Site BS02

Receptor Information
>8agv Chain a (length=848) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKL
NVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRI
LVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYE
MFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIK
QLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSES
CLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTA
DLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYA
LRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIE
EVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISV
KLDLSSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMK
NIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSP
AETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMS
SSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPP
AQLVMGFGFLWKVKSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLK
GIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKH
KSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEI
LHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTI
Ligand information
>8agv Chain x (length=74) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcguguggcguagucgagcgcgcucccuuagcaugggagaggucuccg
guucgauuccggacucguccgcca
<<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<
<.......>>>>>..>>>>>....
Receptor-Ligand Complex Structure
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PDB8agv Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q3 R4 Q97 D98 R99 F117 S118 A119 E140 M151 K348 N538 N545 I546 K549
Binding residue
(residue number reindexed from 1)		Q3 R4 Q97 D98 R99 F117 S118 A119 E140 M151 K348 N494 N501 I502 K505
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003729 mRNA binding
GO:0043023 ribosomal large subunit binding
GO:1904678 alpha-aminoacyl-tRNA binding
Biological Process
GO:0006412 translation
GO:0043043 peptide biosynthetic process
GO:0072344 rescue of stalled ribosome
GO:0140708 CAT tailing
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0022626 cytosolic ribosome
GO:1990112 RQC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8agv, PDBe:8agv, PDBj:8agv
PDBsum8agv
PubMed36804914
UniProtQ12532|RQC2_YEAST Ribosome quality control complex subunit 2 (Gene Name=RQC2)

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