Structure of PDB 8agt Chain a Binding Site BS02

Receptor Information
>8agt Chain a (length=848) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKQRISALDLLLLARELKQDLEGYRLSNIYNIADSSKQFLLKFNKPDSKL
NVVVDCGLRIYLTEFSRPIPPTPSGFVVKLRKHLKAKRLTALKQVDQDRI
LVLQFADGHFYLVLEFFSAGNVILLDENRRIMALQRVVLEHENKVGQIYE
MFDESLFTTNNESADESIEKNRKAEYTSELVNEWIKAVQAKYESDITVIK
QLNIQGKEGAKKKKVKVPSIHKLLLSKVPHLSSDLLSKNLKVFNIDPSES
CLNLLEETDSLAELLNSTQLEYNQLLTTTDRKGYILAKRNENYISEKDTA
DLEFIYDTFHPFKPYINGGDTDSSCIIEVEGPYNRTLDKFFSTIESSKYA
LRIQNQESQAQKKIDDARAENDRKIQALLDVQELNERKGHLIIENAPLIE
EVKLAVQGLIDQQMDWNTIEKLIKSEQKKGNRIAQLLNLPLNLKQNKISV
KLDLSSNEKINVTIDLGLSAYANATEYFNIKKTSAQKQKKVEKNVGKAMK
NIEVKIDQQLKKKLKDSHSVLKKIRTPYFFEKYSWFISSEGFLVMMGKSP
AETDQIYSKYIEDDDIYMSNSFNSHVWIKNPEKTEVPPNTLMQAGILCMS
SSEAWSKKISSSPWWCFAKNVSKFDGSDNSILPEGAFRLKNENDQNHLPP
AQLVMGFGFLWKVKSNVRGKRGKLKKIQKKYADQDETERLLRLEALGTLK
GIEKQQQRKKEEIMKREVREDRKNKREKQRRLQALKFTKKEKARVNYDKH
KSELKPSLDKGDVVDDIIPVFAPWPALLKYKYKVKIQPGSAKKTKTLTEI
LHYFKSRPLDGSSTDNEMDWPQEHEMIKGLKEQDLVLLLCVDKLKVTI
Ligand information
>8agt Chain x (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcguguggcguagucgagcgcgcucccuuagcaugggagaggucuccg
guucgauuccggacucguccgccaA
<<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<
<.......>>>>>..>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8agt Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
K2 Q3 R4 Q97 D98 R99 F117 A119 V138 E140 H141 M151 K348 R352 N538 N545 I546 K549
Binding residue
(residue number reindexed from 1)
K2 Q3 R4 Q97 D98 R99 F117 A119 V138 E140 H141 M151 K348 R352 N494 N501 I502 K505
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003729 mRNA binding
GO:0043023 ribosomal large subunit binding
GO:1904678 alpha-aminoacyl-tRNA binding
Biological Process
GO:0006412 translation
GO:0043043 peptide biosynthetic process
GO:0072344 rescue of stalled ribosome
GO:0140708 CAT tailing
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0022626 cytosolic ribosome
GO:1990112 RQC complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8agt, PDBe:8agt, PDBj:8agt
PDBsum8agt
PubMed36804914
UniProtQ12532|RQC2_YEAST Ribosome quality control complex subunit 2 (Gene Name=RQC2)

[Back to BioLiP]