Structure of PDB 6qx2 Chain a Binding Site BS02

Receptor Information
>6qx2 Chain a (length=481) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTP
DKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNF
GSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVL
PARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELM
EDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIV
VTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRK
DANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQK
TVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMES
LQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILA
DEEVLLQLVRDELTEIRDRFGDDRRTEIQLG
Ligand information
Receptor-Ligand Complex Structure
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PDB6qx2 Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		I175 G178 M179 G332
Binding residue
(residue number reindexed from 1)		I165 G168 M169 G322
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6qx2, PDBe:6qx2, PDBj:6qx2
PDBsum6qx2
PubMed30962087
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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