Structure of PDB 6la2 Chain a Binding Site BS02

Receptor Information

>6la2 Chain a (length=103) Species: 9606 (Homo sapiens)

TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILEL
AGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVL
LPK

Ligand information

>6la2 Chain d (length=343)

cgctgttttttttcatgtgccggtctcacacgtgcctggagactagtaag
cgcttctagtggcggttaaaacgcggtagacagcgcgtacgtgcgtttaa
gcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggatg
cgttttttttttcatactcgagcatgcttttttttttcatgtgccggtct
cacacgtgcctggagactagtaagcgcttctagtggcggttaaaacgcgg
tagacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaa
ttgagcggcctcggcaccgggatgcgttttttttcagcggtac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6la2 Engineering nucleosomes for generating diverse chromatin assemblies.
• Resolution: 3.89 Å
• Binding residue (original residue number in PDB): R29 R42 V43 K75 T76 R77
• Binding residue (residue number reindexed from 1): R14 R27 V28 K60 T61 R62

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0008285 negative regulation of cell population proliferation
• GO:0031507 heterochromatin formation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6la2, PDBe:6la2, PDBj:6la2
• PDBsum: 6la2
• PubMed: 33590100
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)