Structure of PDB 5gm6 Chain a Binding Site BS02

Receptor Information

>5gm6 Chain a (length=123) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NQPTNIRTTVLMDFQPDVCKDYKQTGYCGYGDSCKFLHSRDDFKTGWKLN
QEWNDLEKIPFKCTLCKEDYKSPVVTNCGHYFCGSCFAKDMKKGTKCFIC
HKETHGSAKVASDLQKMLNKRKS

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

5gm6 Chain a Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	5gm6 Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Resolution	3.5 Å
Binding residue (original residue number in PDB)	C144 C153 C159 H163
Binding residue (residue number reindexed from 1)	C19 C28 C34 H38
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0000349	generation of catalytic spliceosome for first transesterification step
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0034247	snoRNA splicing

	Cellular Component
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005684	U2-type spliceosomal complex

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Cellular Component

External links

PDB	RCSB:5gm6, PDBe:5gm6, PDBj:5gm6
PDBsum	5gm6
PubMed	27445306
UniProt	P53769\|CWC24_YEAST Pre-mRNA-splicing factor CWC24 (Gene Name=CWC24)

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