Structure of PDB 6gzz Chain Z2 Binding Site BS02

Receptor Information

>6gzz Chain Z2 (length=63) Species: 300852 (Thermus thermophilus HB8)

MKEGIHPKLVPARIICGCGNVIETYSTKPEIYVEVCSKCHPFYTGQQRFV
DTEGRVERFQRRY

Ligand information

>6gzz Chain A4 (length=1506)

uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauc

....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<
.<<<..<<<..<<...........................>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<.<...
...>.>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....
.............>>>>>..>>>>>>>>>><<<....<<....<<<<<<<
.......>>>>>>>..>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<............>>>>>.<<........>>...>>>>>>
..........<<....<<<<....>>>>..>>....>.>>>>>>..<<<<
......<<<......>>>.....>>>>....<<<<<........<<<<..
...>>>>..........>>>>>......<<<<<(((...<<<<<.....<
..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((
.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>..>>>...>>>>...<<<....<....<<<<<
<....<<<<<<<....<<<......>>>.......>>>>>>>........
...<......>.>>>>>>...>.....>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>...)))..<.<<<.<
<<<<<<....<<<<<<....<<<<<<........<<........>>....
......<<<<...........<<<.........<<<....>>>.......
.................>>>....<.......<<<.<........<<<<<
<<<......>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<
<<...<...............>....>>>>>>>.....<<<<<....>>>
>>........>>>>..........>....>>>.....>......>>>.>.
....>>>>>>.......<<<<<.......<<<......<<........>>
........>>>.......>>>>>...........<<<<<<<........>
>>>>>>..........>>>>>>.....<<<<<............>>>>>.
...........>>>>>>>>>>..>............<<<<.<<<..<<<<
<<<<<<<<<...<.<<<.....<<......>>..>>>.>..>>>>>>>>>
>>>>..>>>.>>>>...............<<<<<<<<<....>>>>>>>>
>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6gzz Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
• Resolution: 4.13 Å
• Binding residue (original residue number in PDB): R61 R62
• Binding residue (residue number reindexed from 1): R61 R62

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6gzz, PDBe:6gzz, PDBj:6gzz
• PDBsum: 6gzz
• PubMed: 30301898
• UniProt: Q5SJE1|RL31_THET8 Large ribosomal subunit protein bL31 (Gene Name=rpmE)