Structure of PDB 7mxw Chain Z Binding Site BS02

Receptor Information
>7mxw Chain Z (length=350) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEP
TDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLL
KGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEA
DAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLG
MCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIV
KVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAY
EDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAENLYF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mxw Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
Resolution2.836 Å
Binding residue
(original residue number in PDB)		H36 K85 R92 R96 I125 E150 D152 D171 K185 D225
Binding residue
(residue number reindexed from 1)		H35 K84 R91 R95 I124 E149 D151 D170 K184 D224
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7mxw, PDBe:7mxw, PDBj:7mxw
PDBsum7mxw
PubMed
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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