Structure of PDB 7mxr Chain Z Binding Site BS02

Receptor Information
>7mxr Chain Z (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEP
TDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLL
KGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEA
DAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLG
MCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIV
KVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAY
EDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTALY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mxr Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
Resolution3.101 Å
Binding residue
(original residue number in PDB)		G2 L7 H36 D78 K85 E89 R92 D171 S172 K185
Binding residue
(residue number reindexed from 1)		G1 L6 H35 D77 K84 E88 R91 D170 S171 K184
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7mxr, PDBe:7mxr, PDBj:7mxr
PDBsum7mxr
PubMed
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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