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Receptor Information

>5uz4 Chain Z (length=323) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LSKGQQRRVNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVE
SADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTS
VLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEP
IIVLNKIDLLDDEGMAFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEAL
TGRISIFAGQSGVGKSSLLNALLGLQKEILTNDISDARLYHFPHGGDVID
SPGVREFGLWHLEPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAV
EEGKIAETRFENYHRILESMAQV

Ligand ID

GGM

InChI

InChI=1S/C18H24N7O14P3/c1-20-9-5-3-2-4-8(9)17(28)38-13-10(6-36-42(34,35)39-41(32,33)24-40(29,30)31)37-16(12(13)26)25-7-21-11-14(25)22-18(19)23-15(11)27/h2-5,7,10,12-13,16,20,26H,6H2,1H3,(H,34,35)(H3,19,22,23,27)(H4,24,29,30,31,32,33)/t10-,12-,13-,16-/m1/s1

InChIKey

ZGTKZICAFACDSP-XNIJJKJLSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.2	CNc1ccccc1C(=O)O[C@@H]2[C@H](O[C@H]([C@@H]2O)n3cnc4c3N=C(NC4=O)N)CO[P@](=O)(O)O[P@](=O)(NP(=O)(O)O)O
CACTVS 3.370	CNc1ccccc1C(=O)O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)n3cnc4C(=O)NC(=Nc34)N
CACTVS 3.370	CNc1ccccc1C(=O)O[CH]2[CH](O)[CH](O[CH]2CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)n3cnc4C(=O)NC(=Nc34)N
OpenEye OEToolkits 1.7.2	CNc1ccccc1C(=O)OC2C(OC(C2O)n3cnc4c3N=C(NC4=O)N)COP(=O)(O)OP(=O)(NP(=O)(O)O)O
ACDLabs 12.01	O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC4OC(n2cnc1c2N=C(N)NC1=O)C(O)C4OC(=O)c3ccccc3NC

Formula

C18 H24 N7 O14 P3

Name

3'-O-(N-methylanthraniloyl)-beta:gamma-imidoguanosine-5'-triphosphate;
MANT-GMPPNP

PDB chain

5uz4 Chain Z Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5uz4 The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly.
Resolution	5.8 Å
Binding residue (original residue number in PDB)	N160 K161 S191 S192 H193 G219 K220 S221 S222 L235 T236 N237 D241
Binding residue (residue number reindexed from 1)	N155 K156 S186 S187 H188 G214 K215 S216 S217 L230 T231 N232 D236
Annotation score	2

Enzyme Commision number

3.6.1.-

	Molecular Function
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016787	hydrolase activity
GO:0019003	GDP binding
GO:0019843	rRNA binding
GO:0046872	metal ion binding
GO:0097216	guanosine tetraphosphate binding

	Biological Process
GO:0000028	ribosomal small subunit assembly
GO:0042254	ribosome biogenesis
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

PDB	RCSB:5uz4, PDBe:5uz4, PDBj:5uz4
PDBsum	5uz4
PubMed	28396444
UniProt	P39286\|RSGA_ECOLI Small ribosomal subunit biogenesis GTPase RsgA (Gene Name=rsgA)

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Structure of PDB 5uz4 Chain Z Binding Site BS02