Structure of PDB 5m2b Chain Z Binding Site BS02

Receptor Information
>5m2b Chain Z (length=222) Species: 9606,559292 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNI
VMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSR
RFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFL
DNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5m2b Chain Z Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5m2b Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		T192 H195 V198
Binding residue
(residue number reindexed from 1)		T192 H195 V198
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Gene Ontology
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5m2b, PDBe:5m2b, PDBj:5m2b
PDBsum5m2b
PubMed28098422
UniProtP20618|PSB1_HUMAN Proteasome subunit beta type-1 (Gene Name=PSMB1);
P23724|PSB6_YEAST Proteasome subunit beta type-6 (Gene Name=PRE7)

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