Structure of PDB 5a2q Chain Z Binding Site BS02

Receptor Information
>5a2q Chain Z (length=72) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQEL
LSKGLIKLVSKHRAQVIYTRNT
Ligand information
>5a2q Chain 3 (length=257) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuccccugugaggaacuacugucuucacgcagaaagcgucuagccauggc
guuaguaugagugucgugcagccuccaggacccccccucccgggagagcc
auaguggucugcggaaccggugaguacaccggaauugcgagauuugggcg
ugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuug
ugguacugccugauagggugcuugcgagugccccgggaggucucguagac
caccaug
....<<<<.<<<<.....<<<<<..<<<.<<....<<<<<.......>>>
>>.....>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<
<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<.
.>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....
>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))....
.......
Receptor-Ligand Complex Structure
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PDB5a2q Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution
Resolution3.9 Å
Binding residue
(original residue number in PDB)		E61 N64 Y65 E75 R76
Binding residue
(residue number reindexed from 1)		E20 N23 Y24 E34 R35
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a2q, PDBe:5a2q, PDBj:5a2q
PDBsum5a2q
PubMed26155016
UniProtP62851|RS25_HUMAN Small ribosomal subunit protein eS25 (Gene Name=RPS25)

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