Structure of PDB 3qe9 Chain Z Binding Site BS02

Receptor Information
>3qe9 Chain Z (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEP
TDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLL
KGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEA
DAQLAYLNKAGIVQAIITEDSALLAFGCKKVILKMDQFGNGLEIDQARLG
MCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIV
KVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAY
EDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3qe9 Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		L7 Q8 H36 R92 R95 R121 K185
Binding residue
(residue number reindexed from 1)		L6 Q7 H35 R91 R94 R120 K184
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3qe9, PDBe:3qe9, PDBj:3qe9
PDBsum3qe9
PubMed21496642
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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