Structure of PDB 4r18 Chain Y Binding Site BS02
Receptor Information
>4r18 Chain Y (length=211) Species:
559292
(Saccharomyces cerevisiae S288C) [
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TTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAAD
CQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMI
CGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVE
DALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVK
EEEGSFNNVIG
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
4r18 Chain Y Residue 302 [
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Receptor-Ligand Complex Structure
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PDB
4r18
Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
A165 D168 A169 S171
Binding residue
(residue number reindexed from 1)
A164 D167 A168 S170
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
D17 R19 K33 G47 S131 D168 S171
Catalytic site (residue number reindexed from 1)
D16 R18 K32 G46 S130 D167 S170
Enzyme Commision number
3.4.25.1
: proteasome endopeptidase complex.
Gene Ontology
Molecular Function
GO:0004298
threonine-type endopeptidase activity
Biological Process
GO:0051603
proteolysis involved in protein catabolic process
Cellular Component
GO:0005839
proteasome core complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:4r18
,
PDBe:4r18
,
PDBj:4r18
PDBsum
4r18
PubMed
25244435
UniProt
P30656
|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)
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