Structure of PDB 7aoi Chain XB Binding Site BS02

Receptor Information
>7aoi Chain XB (length=614) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPQQLKAYGGTFSRSVGERSNHLVSDVVLQSLSPSSTHNSPLLSKNIKTK
TVTSFEDMPLYPELRSALRQLRITTPSPIQQSAVEVIMQRKDTVVAAPHG
EGKTLAYLLPLYQNMIKDRDVYKIPLRERRPRMILLAPTRELIAQLHHVC
SVLGEATGLHAISFTSRKRANHRLSRLLKQQLVDVMIMDPKIVLRLIRAR
RVFLDDLRYVAVDEADGMLSSQHDHDAVHLLMKVQKRVMFKHLWPVQTQT
VFATAFITRKLEFVVGKKYPDAVTCIRRQRMHRPPGTLRHRFLPVERERE
KMDTLQHLLKKHGNRPREILTDIEEEQAYSKPHYLSGSLEELVELDEMKE
RVRHALEGVRPVHWGHLTTVAAPFTCHVPRTVFADGKRCIIFTRGIDCAT
AVYHRLRGCGYTCSLLHAALPAAVRRRMFADFASGRTNILCSTDVAARGL
DLHVDFVVNFDMPTNALTYLSRAGRTARQGRLGQVYSLYTKRQGVIVSAV
RAFLQKQLPLEGISNWKRHMMEPRYAEWRTHKLNAIARSYVSLITQKTIP
AHLERTYLRHNATWRPLFHPQTTGVHGGVPPRQQQRVMDAITWKAVCFRR
GLLARRKGGRAKFG
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7aoi Chain XB Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7aoi Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		I119 T121 Q126 H145 G146 G148 K149 T150 A469 D548 R575 Q576
Binding residue
(residue number reindexed from 1)		I73 T75 Q80 H99 G100 G102 K103 T104 A372 D451 R478 Q479
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7aoi, PDBe:7aoi, PDBj:7aoi
PDBsum7aoi
PubMed33576519
UniProtD0A9G9

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