Structure of PDB 8fru Chain X Binding Site BS02

Receptor Information
>8fru Chain X (length=116) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTNVHFFRPKTLVHKKAPLYPRNPIKKGSWDDPCDLLRYPIKTDENTTQI
EKNNTIVFIVDRRASKPEIRKAFETVFETKVARVNTLITPLGLKKAFIRL
APDVQAMDVASKMGLA
Ligand information
>8fru Chain 1 (length=2551) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguac
gccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgg
gaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggc
ccgagggccccgcccgagagggugcaagccccguacggcgggcggcgagu
agcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcu
aaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacgguga
aaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccgg
cccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcg
agcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccg
ccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaa
aggcggugaucuaugcccggcgagggcgaggccgggcgaaagccuggugg
aggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugg
gggcgaaagacucaucgaaccgccugguagcugguugccuccgaaauguc
ucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccgg
cgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccc
cgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccu
ccugguaagcaggacgggcgaggcgggacgauccggacgccgggccaggg
ugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccg
aaucggccggcccggaaaauggagcgcgccggagccccggacccgcgccc
ggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaagg
cggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcag
uagccgcuacuccgcgccccggaggacugagggggagacggguuccgcgg
cgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagacc
gggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggc
aggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggac
cgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgcc
uugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgcc
ccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcagga
cuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagu
cggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgg
gucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacag
cgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagug
ccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcggg
aguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuucc
gacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuc
cgcgagccuccagccucgggaacgggcgagggccggccagcggggcaaga
agacccuuuugagcuugacuccagcccgggccuguggggcgggggccgcc
gccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucg
gcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggc
ucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccg
acccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauc
cuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagg
gauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugau
ccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgu
cggauuguucacccguucaagggaucgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuggccccggggccagagcacggcgggcc
aguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggc
cgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucua
agcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgug
ccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuc
cuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcg
c
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>
>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<
......>>>>>((......<<<.....))>>>...>>>>>>>>.......
.<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]].
.................................<<....>>.........
.......<<<....>>>............................<<<<<
<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<.
.<<<...<<<....>>>..>>>...<<....>>............<<<<<
<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..
<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>..
...>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>..
.<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<
<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<
<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<
<(((...<<<<<<<........<<<.<<<<<<<<<...............
..>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>
>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<
<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<...
..<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<
...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>
......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>
))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<
<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.
....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.
........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.
>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<
<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<
<<<.......>>>>>>........<...........<<<<<<.....>>>
>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>
>>>....>>....<<<<<........>>>>>...((((((..{{{.....
....{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<........
.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...
<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<
...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>..
.<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......
(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<.
..............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}
.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........
>>>>>>...>>>..>>>..>>>>>....<<<<<<................
............>>>>>>.....<<<<<.......>>>>..<<<<<<<<<
<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>..
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fru The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		H30 F32 R33 K35 H39 K41 A42 P43 L44 R47 E70 S90 K91 R108 N110 L112 P115 F122
Binding residue
(residue number reindexed from 1)		H5 F7 R8 K10 H14 K16 A17 P18 L19 R22 E45 S65 K66 R83 N85 L87 P90 F97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fru, PDBe:8fru, PDBj:8fru
PDBsum8fru
PubMed38242118
UniProtA8BMP6

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