Structure of PDB 7nwi Chain X Binding Site BS02

Receptor Information

>7nwi Chain X (length=119) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAM
KKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAY
VRLAPDYDALDVANKIGII

Ligand information

>7nwi Chain 8 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>.............>>>..)...>>
>....<<<..>>><<<<<<<<.......>>>>>>>>..............
......

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7nwi Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Resolution	3.13 Å
Binding residue (original residue number in PDB)	K63 R68 K70
Binding residue (residue number reindexed from 1)	K26 R31 K33

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:7nwi, PDBe:7nwi, PDBj:7nwi
PDBsum	7nwi
PubMed	34157102
UniProt	G1SE76\|RL23A_RABIT Large ribosomal subunit protein uL23 (Gene Name=RPL23A)

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