Structure of PDB 6hmz Chain X Binding Site BS02

Receptor Information

>6hmz Chain X (length=170) Species: 3708 (Brassica napus)

ANPKVFFDILIGKMKAGRVVMELFADVTPRTADNFRALCTGEKGIGQAGK
ALHYKGSAFHRIIPGFMCQGGDFTRGNGTGGESIYGAKFQDENFKLKHTG
PGILSMANSGPNTNGSQFFICTDKTAWLDGKHVVFGKVVDGYNVVKAMEK
VGSERGVTSEPVVIEDCGEI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6hmz Chain X Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hmz Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): A38 G42 E43 K44 L53
• Binding residue (residue number reindexed from 1): A37 G41 E42 K43 L52
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R62 F67 Q70 N109 F120 L129 H133
• Catalytic site (residue number reindexed from 1): R61 F66 Q69 N108 F119 L128 H132
• Enzyme Commision number: 5.2.1.8: peptidylprolyl isomerase.

Gene Ontology

Molecular Function

• GO:0003755 peptidyl-prolyl cis-trans isomerase activity
• GO:0016018 cyclosporin A binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000413 protein peptidyl-prolyl isomerization
• GO:0006457 protein folding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6hmz, PDBe:6hmz, PDBj:6hmz
• PDBsum: 6hmz
• PubMed: 31249367
• UniProt: A0A078GRH6