Structure of PDB 2h7g Chain X Binding Site BS02

Receptor Information
>2h7g Chain X (length=312) Species: 10255 (Variola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRALFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYGQTW
EEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINS
FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKN
KHIEISPDKIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLF
NKLSERKVYESIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKK
LIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEF
LSIVVDHVKSST
Ligand information
Receptor-Ligand Complex Structure
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PDB2h7g Structural basis for specificity in the poxvirus topoisomerase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 Y209 K220
Binding residue
(residue number reindexed from 1)		H39 R67 Q69 R130 F131 G132 K133 Y136 N140 T142 K167 D168 Y209 K220
Enzymatic activity
Catalytic site (original residue number in PDB) R130
Catalytic site (residue number reindexed from 1) R130
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h7g, PDBe:2h7g, PDBj:2h7g
PDBsum2h7g
PubMed16885024
UniProtP32989|TOP1_VAR67 DNA topoisomerase 1 (Gene Name=OPG111)

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