Structure of PDB 1pcj Chain X Binding Site BS02

Receptor Information
>1pcj Chain X (length=458) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPCVAVGR
DGRLSGPELVKQLIQGLVDCGCQVSDVGMVPTPVLYYAANVLEGKSGVML
TGSHNPPDYNGFKIVVAGETLANEQIQALRERIEKNDLASGVGSVEQVDI
LPRYFKQIRDDIAMAKPMKVVVDCGNGVAGVIAPQLIEALGCSVIPLYCE
VDGNFPNHHPDPGKPENLKDLIAKVKAENADLGLAFDGDGDRVGVVTNTG
TIIYPDRLLMLFAKDVVSRNPGADIIFDVKCTRRLIALISGYGGRPVMWK
TGHSLIKKKMKETGALLAGEMSGHVFFKERWFGFDDGIYSAARLLEILSQ
DQRDSEHVFSAFPSDISTPEINITVTEDSKFAIIEALQRDAQWGEGNITT
LDGVRVDYPKGWGLVRASNTTPVLVLRFEADTEEELERIKTVFRNQLKAV
DSSLPVPF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1pcj Chain X Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1pcj Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S108 D242 D244 D246
Binding residue
(residue number reindexed from 1)		S103 D237 D239 D241
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R20 S108 H109 K118 D242 D244 D246 R247 H329 D340
Catalytic site (residue number reindexed from 1) R15 S103 H104 K113 D237 D239 D241 R242 H324 D335
Enzyme Commision number 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
5.4.2.8: phosphomannomutase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0004615 phosphomannomutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009243 O antigen biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0042121 alginic acid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1pcj, PDBe:1pcj, PDBj:1pcj
PDBsum1pcj
PubMed14725765
UniProtP26276|ALGC_PSEAE Phosphomannomutase/phosphoglucomutase (Gene Name=algC)

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